Photo by Michael Schuier

Search South Carolina Lowcountry hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Go beyond your typical stay in South Carolina Lowcountry

Check prices for these dates

Filter by

Property class

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for South Carolina Lowcountry hotels

1. Microtel Inn & Suites by Wyndham Walterboro

Microtel Inn & Suites by Wyndham Walterboro
2.0 star property
Walterboro
8.2 out of 10, Very good, (1,003 reviews)
"Great overnight stay."
United States
Jacqueline
The price is AU$155
includes taxes & fees
1 Dec - 2 Dec
Microtel Inn & Suites by Wyndham Walterboro

2. Comfort Inn & Suites Walterboro I-95

Comfort Inn & Suites Walterboro I-95
2.5 star property
Walterboro
8.4 out of 10, Very good, (1,118 reviews)
"Great staff, clean rooms, quiet even though it is just off the interstate."
United States
Nancy
The price is AU$152
includes taxes & fees
22 Nov - 23 Nov
Comfort Inn & Suites Walterboro I-95

3. Holiday Inn Exp Walterboro by IHG

Holiday Inn Exp Walterboro by IHG
2.5 star property
Walterboro
8.6 out of 10, Excellent, (1,000 reviews)
"Dirty. Not a great example of a Holiday Inn Express"
United States
John
The price is AU$189
includes taxes & fees
13 Dec - 14 Dec
Holiday Inn Exp Walterboro by IHG

4. Tru by Hilton Beaufort, SC

Tru by Hilton Beaufort, SC
2.5 star property
Beaufort
9.0 out of 10, Wonderful, (968 reviews)
"Rooms were very clean and the staff were very kind and hospitable"
United States
douglas
The price is AU$138
includes taxes & fees
30 Nov - 1 Dec
Tru by Hilton Beaufort, SC

5. Hampton Inn & Suites Walterboro

Hampton Inn & Suites Walterboro
2.5 star property
Walterboro
9.2 out of 10, Wonderful, (1,002 reviews)
"Great stay!"
United States
Lauren
The price is AU$247
includes taxes & fees
13 Dec - 14 Dec
Hampton Inn & Suites Walterboro

6. SpringHill Suites by Marriott Beaufort

SpringHill Suites by Marriott Beaufort
2.5 star property
Beaufort
9.2 out of 10, Wonderful, (1,107 reviews)
"The room was very clean and this hotel is very convenient to the Beaufort area. We have stayed at this facility numerous times and found the staff extremely friendly and the buffet breakfast is definitely a plus."
United States
Arthur
The price is AU$178
includes taxes & fees
17 Nov - 18 Nov
SpringHill Suites by Marriott Beaufort

7. Quality Inn Walterboro I-95

Quality Inn Walterboro I-95
2.5 star property
Walterboro
7.6 out of 10, Good, (1,002 reviews)
"room and breakfast was great"
Canada
gary
The price is AU$104
includes taxes & fees
13 Dec - 14 Dec
Quality Inn Walterboro I-95

8. Home2 Suites BY Hilton Beaufort, SC

Home2 Suites BY Hilton Beaufort, SC
3.0 star property
Beaufort
9.2 out of 10, Wonderful, (836 reviews)
"Far better than the Homes2Suites we had just stayed ay in Hilton Head"
United States
joe
The price is AU$170
includes taxes & fees
28 Nov - 29 Nov
Home2 Suites BY Hilton Beaufort, SC

9. Moonnight inn.

Moonnight inn.
2.0 star property
Walterboro
8.2 out of 10, Very good, (10 reviews)
"We stay here twice a year on the way to Florida and back."
United States
John
The price is AU$79
includes taxes & fees
15 Dec - 16 Dec
Moonnight inn.

10. Best Western Of Walterboro

Best Western Of Walterboro
2.5 star property
Walterboro
7.6 out of 10, Good, (542 reviews)
"great place to stay while on the road"
United States
Sheldon
The price is AU$153
includes taxes & fees
19 Nov - 20 Nov
Best Western Of Walterboro

11. Hampton Inn Beaufort

Hampton Inn Beaufort
2.5 star property
Beaufort
8.4 out of 10, Very good, (1,001 reviews)
"Spacious room,amazing and friendly staff. I enjoyed everything about my stay."
United States
Thalia
The price is AU$163
includes taxes & fees
4 Dec - 5 Dec
Hampton Inn Beaufort

12. Sleep Inn Walterboro I-95

Sleep Inn Walterboro I-95
2.5 star property
Walterboro
7.6 out of 10, Good, (660 reviews)
"Nice clean well kept hotel. The staff is very courteous and professional."
United States
John
The price is AU$138
includes taxes & fees
6 Dec - 7 Dec
Sleep Inn Walterboro I-95

13. Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG
3.0 star property
Beaufort
8.6 out of 10, Excellent, (1,001 reviews)
"The staff is amazing and so helpful."
United States
Kristina
The price is AU$170
includes taxes & fees
29 Nov - 30 Nov
Holiday Inn Hotel & Suites Beaufort at Highway 21 by IHG

14. Econo Lodge Walterboro I-95

Econo Lodge Walterboro I-95
2.0 star property
Walterboro
7.6 out of 10, Good, (1,001 reviews)
"Great staff. Simple & tidy rooms."
United States
Shannon
The price is AU$77
includes taxes & fees
6 Dec - 7 Dec
Econo Lodge Walterboro I-95

15. Hampton Inn Yemassee/Point South

Hampton Inn Yemassee/Point South
2.5 star property
Yemassee
8.8 out of 10, Excellent, (855 reviews)
"More than enough for free breakfast. tables ,and food area was very clean"
United States
Philip
The price is AU$232
includes taxes & fees
15 Dec - 16 Dec
Hampton Inn Yemassee/Point South

16. Red Roof Inn Yemassee

Red Roof Inn Yemassee
2.0 star property
Yemassee
7.6 out of 10, Good, (682 reviews)
"The elevator is as not operational, but everything was awesome for the price. I had a great stay. It was relaxing and the staff was nice."
United States
DeAngelo
The price is AU$123
includes taxes & fees
15 Nov - 16 Nov
Red Roof Inn Yemassee

17. Quality Inn Yemassee - Point South I-95

Quality Inn Yemassee - Point South I-95
2.5 star property
Yemassee
7.6 out of 10, Good, (346 reviews)
"Room was clean,, bathroom was clean, air conditioner worked great, staff was very friendly, stayed for one night during travel,, right off I95, if you travel with dog plenty area to walk them around some."
United States
Claudia
The price is AU$97
includes taxes & fees
6 Dec - 7 Dec
Quality Inn Yemassee - Point South I-95

18. City Loft Hotel

City Loft Hotel
3.5 star property
Historic District
9.6 out of 10, Exceptional, (905 reviews)
"Great stay!"
United States
Matthew
The price is AU$224
includes taxes & fees
12 Dec - 13 Dec
City Loft Hotel

19. Beaufort Inn

Beaufort Inn
3.5 star property
Historic District
9.0 out of 10, Wonderful, (1,000 reviews)
"Loved location and size of room. Would stay again"
United States
Angela
The price is AU$244
includes taxes & fees
6 Dec - 7 Dec
Beaufort Inn

20. Best Western Sea Island Inn

Best Western Sea Island Inn
2.5 star property
Historic District
9.6 out of 10, Exceptional, (1,002 reviews)
"Staff were welcoming and helpful"
United States
Paul
The price is AU$228
includes taxes & fees
23 Nov - 24 Nov
Best Western Sea Island Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular South Carolina Lowcountry attractions

Learn more about South Carolina Lowcountry

Discover things to see and do in South Carolina Lowcountry as you venture to popular sights like Marine Corps Recruit Depot Parris Island.

A nest with two white birds and a chick.
Photo by Michael Schuier
Open Photo by Michael Schuier

Top South Carolina Lowcountry Hotel Reviews

Explore a world of travel with Expedia